Symptoms may include pain the lower back, urinating less than usual or not urinating at all, easy bruising or bleeding, and unusual weakness. Patients are instructed to consult with their health care provider if they experience any other unusual, severe or troublesome side effects while being treated with acyclovir. Is there an acyclovir ointment? Acyclovir ointment is indicated for the management of initial genital herpes and in limited non-life threatening mucocutaneous herpes simplex virus infections in immunocompromised patients.
Acyclovir ointment is not indicated for the prevention of viral transmission to other individuals. Acyclovir ointment is also not indicated for the prevention of recurrent herpes infections.
Acyclovir ointment is a prescription ointment that is applied directly to genital herpes lesions and may lessen the duration of the symptoms associated with an initial outbreak. For the management of genital herpes, patients should be instructed regarding appropriate dosage and administration of acyclovir ointment. Patients should be advised to apply a sufficient quantity of acyclovir ointment to adequately cover all lesions and apply every 3 hours, 6 times daily, for 7 days of treatment.
The dose size of acyclovir ointment for each application may vary depending on the size of the lesion area. Patients should be advised to wear a rubber glove or finger cot when applying acyclovir ointment to the affected area to avoid spreading the virus.
Acyclovir ointment should be applied as early as possible after the development of signs and symptoms. Patients should be advised not to exceed the recommended dosage, frequency of applications and length of treatment.
How long is acyclovir treatment? How long acyclovir Zovirax treatment is intended for depends upon the indication for use. Acyclovir is a prescription antiviral agent approved, by the U. Food and Drug Administration FDA , for the acute treatment of herpes zoster shingles , the treatment of initial episodes and the management of recurrent episodes of genital herpes and the treatment of chickenpox. Acyclovir treatment is approved for all indications for adults and for the treatment of chickenpox in children 2 year of age and older.
For the acute treatment of shingles, the length of acyclovir treatment is 7 to 10 days. The usual recommended adult dosage is mg administered every 4 hours, 5 times daily. For the treatment of initial episodes of genital herpes, the length of acyclovir treatment is 10 days. For the management of recurrent episodes of genital herpes, there were two methods of administration of acyclovir treatment evaluated in clinical trials.
For intermittent therapy, the length of acyclovir treatment is 5 days. Treatment should be initiated at the earliest sign or symptom of recurrence, known as a prodrome. The usual adult dosage is mg administered every 4 hours, 5 times daily. The other option is chronic suppressive therapy in which acyclovir treatment is used for up to 12 months and followed by re-evaluation by a health care provider to assess the need for continued treatment. The usual adult dosage is mg twice daily.
Alternative dosages may range from mg 3 times daily to mg 5 times daily, according to the prescribing information for Zovirax, the brand-name of acyclovir. For the treatment of chickenpox for adults and children, the recommended length of acyclovir treatment is 5 days. When treatment is required, it should be initiated at the earliest sign or symptom of chickenpox.
The effectiveness of treatment initiated after 24 hours following the onset of symptoms is unknown. The usual dosage for adults and children weighing over 40 kg is mg administered 4 times daily. Does acyclovir cause hair loss? During post marketing experience, observed in clinical practice, acyclovir Zovirax was reported to cause hair loss.
However, because adverse reactions reported in clinical practice, and not during controlled clinical trials, are reported voluntarily from an unknown population size, the frequency of the adverse reaction is unknown.
Your dose will depend upon the type of infection you have, so take aciclovir exactly as your doctor tells you to. Typically, doses range from mg to mg, and these doses are taken either three, four or five times daily. Your doctor or pharmacist will tell you what dose is right for you, and this information will also be printed on the label of the pack to remind you about what was said to you.
Space out your doses evenly during the day. You can take aciclovir either with or without food. Even if you feel your infection has cleared up, keep taking aciclovir until the course is finished unless your doctor tells you to stop sooner. This is to prevent the infection from coming back. The course of treatment prescribed could last between days.
If you still feel unwell after finishing the course, go back to see your doctor. If you have been prescribed a dispersible tablet - these can be stirred into a small glassful 50 ml of water to make them easier to swallow. You can, however, swallow them as normal if you prefer. If you forget to take a dose, take it as soon as you remember and then continue as before. Try to take the correct number of doses each day, but do not take two doses at the same time to make up for a missed dose.
Getting the most from your treatment You should drink plenty while you are on aciclovir to keep your kidneys working well. Drinking water is best, but hot drinks and non-alcoholic cold drinks are also suitable. There was also a significant dose-related decrease in mitotic index with exposure to acyclovir. Thus, all these studies showed that acyclovir does not cause single-gene mutations but is capable of breaking chromosomes. Immunotoxicology Studies Acyclovir was subjected to a number of in vitro and in vivo immunological tests.
In four in vivo tests in mice which measured cell-mediated immunity complement-dependent cellular cytotoxicity, complement-independent cellular cytotoxicity, delayed hypersensitivity and graft vs. However, there was only a small reduction in the circulating hemagglutinin titer from 8. In experiments in mice designed to test whether acyclovir would potentiate the immunosuppressive effect of azathioprine on antibody formation, it was found that the effects of the two drugs were no more than additive.
Studies were carried out to evaluate the influence of acyclovir in vitro on human lymphocyte function. These inhibitory concentrations are far in excess of anticipated levels from doses selected for clinical application and over 1,fold higher than the concentration required to inhibit herpesvirus multiplication in vitro.
The effect of acyclovir on human cells was measured. A concentration of The magnitude of this effect was less than that caused by adenine arabinoside or human leukocyte interferon when these three antiviral agents were compared at clinically relevant concentrations. Acyclovir also inhibited thymidine incorporation by peripheral blood mononuclear cells stimulated by PHA or three different herpesvirus antigens. Inhibition was exerted on T-cell proliferation without apparent effect on the release of lymphokines or on monocyte function.
Acyclovir treatment of varicella in otherwise healthy children. J Pediatr ; 4: Acyclovir treatment of varicella in otherwise healthy adolescents. J Pediatr ; 4 Pt 1: Viral resistance in clinical practice: Viral resistance, clinical experience. Scand J Infect Dis Suppl ; Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro.
Am J Med ; 73 1A: Multiple dose pharmacokinetics of intravenous acyclovir in patients on continuous ambulatory peritoneal dialysis. J Antimicrob Chemother ; 20 1: Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir.
A randomized double-blind controlled trial in normal subjects. N Engl J Med ; Isolation and characterisation of resistant Herpes simplex virus after acyclovir therapy.
Lancet ; 1 Christophers J, Sutton RN. Characterisation of acyclovir-resistant and -sensitive clinical herpes simplex virus isolates from an immunocompromised patient.
J Antimicrob Chemother ; 20 3: Varicella-Zoster virus does not become more resistant to acyclovir during therapy. J Infect Dis ; 3: Collins P, Bauer DJ. The activity in vitro against herpes virus of 9- 2-hydroxyethoxymethyl guanine acycloguanosine , a new antiviral agent. J Antimicrob Chemother ; 5 4: Collins P, Oliver NM. Sensitivity monitoring of herpes simplex virus isolates from patients receiving acyclovir.
J Antimicrob Chemother ; 18 Suppl B: Viral sensitivity following the introduction of acyclovir. Am J Med ; 85 2A: Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir.
If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects.
You may report side effects to Health Canada at List Acyclovir side effects by likelihood and severity. Precautions Before taking acyclovir , tell your doctor or pharmacist if you are allergic to it; or to valacyclovir ; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication , tell your doctor or pharmacist your medical history, especially of: This drug may rarely make you dizzy or drowsy.
Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products. Acyclovir does not protect against the spread of genital herpes.
To lower the chance of giving herpes to your partner, do not have sexual contact during an outbreak or if you have symptoms. You can spread genital herpes even if you do not have symptoms. Consult your doctor or pharmacist for more details. During pregnancy , this medication should be used only when clearly needed.
Discuss the risks and benefits with your doctor. This medication passes into breast milk.
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